Fall Graduate Research Intern - Machine Learning for Protein Structure Prediction
Iambic TherapeuticsJOB SUMMARY
We are seeking a graduate student for a research internship at Iambic Therapeutics to contribute to the development of NeuralPLexer, our protein structure prediction platform. This internship offers an exciting opportunity to work on cutting-edge machine learning approaches for structural biology, with a focus on understanding protein conformational dynamics and affinity. You will join a collaborative team developing next-generation methods that combine deep learning with physics-based approaches.
This will be a part-time, paid internship for Fall of 2025.
KEY RESPONSIBILITIES
Help develop and train deep learning models for protein structure prediction
Work with molecular dynamics simulations and enhanced sampling techniques to validate and improve model predictions
Analyze large-scale protein structural data to identify patterns in conformational changes
Assist in implementing new model architectures and training strategies
Contribute to our model evaluation framework, particularly for conformational accuracy
Participate in team meetings and present findings to the computational group
PREFERRED QUALIFICATIONS:
Currently enrolled in a PhD program in Computational Chemistry, Computational Biophysics, Computer Science, Computational Biology, or related field
Experience with Python
Experience with enhanced sampling and classical molecular dynamics simulations
Experience with deep learning frameworks (PyTorch preferred)
Understanding of protein structure and protein dynamics
Interest in scientific machine learning applications
LEARNING OPPORTUNITIES
Work with state-of-the-art protein structure prediction models
Learn to integrate physical principles into machine learning approaches
Gain experience with enhanced sampling methods
Understand real-world applications in drug discovery
Collaborate with experts in both ML and computational chemistry
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.